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Travel health · sourced from ITM Antwerp

South Africa

The vaccines usually advised for South Africa when departing from Belgium, with the lead times to respect, based on the Institute of Tropical Medicine Antwerp (ITM).

Yellow feverConditionalMalariaLimited · by region
emmunity editorial team · sourced & datedLast updated 17 August 2026

Overview

South Africa requires no vaccine to enter from Belgium; the usual travel vaccines are recommended. The one local point is malaria, confined to the north-east; most tourist areas (Cape Town, the Garden Route, the Western Cape) are malaria-free.

Best time to go

To limit malaria risk, the dry season (June–August) is most favourable in the north-east.

Recommended vaccines

VaccineCategoryWhen
Hepatitis ARecommendedas early as possible (1st dose already protective)
Diphtheria-tetanus-pertussis (DTPa)Recommendedkeep the booster current (every 10 years)
PolioRecommendedbooster for 16+ to Asia/Africa; sometimes compulsory (long stays)
Measles-mumps-rubella (MMR)Recommendedbe up to date (2 doses) before departure
Typhoid feverConsider≥14 days before departure
RabiesConsiderpre-exposure: 2 doses, start early enough
Hepatitis BConsiderstart early (multi-week schedule)

Malaria by region

In the at-risk north-east, preventive tablets are advised September–May; June–August, bite protection alone, except for higher-risk travellers.

Risk varies by region

Malaria risk is limited to certain regions, shown below.

High risk

North-east of Mpumalanga and Limpopo, including Kruger and the neighbouring parks (mainly September–May).

Low risk

KwaZulu-Natal parks (Tembe, Ndumo, iSimangaliso, Hluhluwe–iMfolozi) and the rest of Limpopo/Mpumalanga (Waterberg, Marakele, Madikwe): low, year-round.

No risk

The south and west of the country, including Cape Town and the Garden Route.

Seasonality

Risk is highest from September to May; from June to August it drops and bite protection is usually enough.

Other health risks

Tick-bite fever
African tick-bite fever in bush and long grass: cover up and check for ticks.
Rabies
Rabies is present in dogs and other mammals; avoid contact and seek care after a bite.
Bilharzia (schistosomiasis)
Bilharzia in some northern lakes and rivers: avoid swimming in fresh water there.
Altitude sickness
Altitude sickness is possible above about 2,500 m.

Prepare your trip

8 weeks
Book a travel clinic
10 days
Yellow fever (if required)
Departure
Certificates & reminders ready

Leaving in under 2 weeks? Still book a clinic: a first hepatitis A dose already protects, and yellow fever needs at least 10 days. A travel clinic will prioritise what fits your timeline.

Frequently asked questions

Is any vaccine required for South Africa?

No vaccine is required if you arrive directly from Belgium. Yellow fever is only asked for if you come from (or transit through) a country where it circulates.

Is there a malaria risk?

Malaria: risk limited to certain regions. Risk is highest from September to May; from June to August it drops and bite protection is usually enough. In the at-risk north-east, preventive tablets are advised September–May; June–August, bite protection alone, except for higher-risk travellers.

How far ahead of departure should I start?

Ideally 6 to 8 weeks before departure, to complete multi-dose schedules. Yellow fever, where it applies, must be given at least 10 days before arrival.

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Our sources

Last updated 17 August 2026

Indicative information for a typical traveller, not medical advice. What you need depends on your itinerary, region, season and duration. See an approved travel clinic 6–8 weeks before departure: only they can give yellow fever and issue the certificate.

Entry formalities: see FPS Foreign Affairs ↗

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